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COMMUNICATIONS
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765-768
 2 Adrenoceptor Agonists as Potential Analgesic Agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphtheneas a High-Affinity Ligand for the 2D Adrenergic Receptor
Tina M. Ross,
Michele C. Jetter,
Mark E. McDonnell,
Robert E. Boyd,
Charlene D. Connelly,
Rebecca P. Martinez,
Martin A. Lewis,
Ellen E. Codd,
Robert B. Raffa, and
Allen B. Reitz
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769-771
1-(2-Nitrophenyl)thiosemicarbazides: A Novel Class of Potent, Orally Active Non-Peptide Antagonist for the Bradykinin B2 Receptor
Edward K. Dziadulewicz,
Timothy J. Ritchie,
Allan Hallett,
Christopher R. Snell,
Soo Y. Ko,
Roger Wrigglesworth,
Glyn A. Hughes,
Andrew R. Dunstan,
Graham C. Bloomfield,
Gillian S. Drake,
Michael C. Brown,
Wai Lee,
Gillian M. Burgess,
Clare Davis,
Mohammed Yaqoob,
Martin N. Perkins,
Elizabeth A. Campbell,
Andrew J. Davis, and
Humphrey P. Rang
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772-774
Dual Function Glutamate-Related Ligands: Discovery of a Novel, Potent Inhibitor of Glutamate Carboxypeptidase II Possessing mGluR3 Agonist Activity
Fajun Nan,
Tomasz Bzdega,
Sergey Pshenichkin,
Jarda T. Wroblewski,
Barbara Wroblewska,
Joseph H. Neale, and
Alan P. Kozikowski
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775-777
4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2
John J. Talley,
David L. Brown,
Jeffery S. Carter,
Matthew J. Graneto,
Carol M. Koboldt,
Jaime L. Masferrer,
William E. Perkins,
Roland S. Rogers,
Alexander F. Shaffer,
Yan Y. Zhang,
Ben S. Zweifel, and
Karen Seibert
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ARTICLES
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778-783
Potent Anti-HIV (Type 1 and Type 2) Activity of Polyoxometalates: Structure-Activity Relationship and Mechanism of Action
Myriam Witvrouw,
Helmut Weigold,
Christophe Pannecouque,
Dominique Schols,
Erik De Clercq, and
George Holan
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784-796
Design of Potent Dicyclic (4-10/5-8) Gonadotropin Releasing Hormone (GnRH) Antagonists
Jean E. Rivier,
R. Scott Struthers,
John Porter,
Sabine L. Lahrichi,
Guangcheng Jiang,
Laura A. Cervini,
Michel Ibea,
Dean A. Kirby,
Steven C. Koerber, and
Catherine L. Rivier
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797-806
Design of Monocyclic (1-3) and Dicyclic (1-3/4-10) Gonadotropin Releasing Hormone (GnRH) Antagonists
Jean E. Rivier,
John Porter,
Laura A. Cervini,
Sabine L. Lahrichi,
Dean A. Kirby,
R. Scott Struthers,
Steven C. Koerber, and
Catherine L. Rivier
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807-818
Design of Potent Dicyclic (1-5/4-10) Gonadotropin Releasing Hormone (GnRH) Antagonists
Jean E. Rivier,
Guangcheng Jiang,
R. Scott Struthers,
Steven C. Koerber,
John Porter,
Laura A. Cervini,
Dean A. Kirby,
A. Grey Craig, and
Catherine L. Rivier
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819-828
Consensus Bioactive Conformation of Cyclic GnRH Antagonists Defined by NMR and Molecular Modeling
Steven C. Koerber,
Josep Rizo,
R. Scott Struthers, and
Jean E. Rivier
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829-842
Synthesis, Biological Activity, and Molecular Modeling of Ribose-Modified Deoxyadenosine Bisphosphate Analogues as P2Y1 Receptor Ligands
Erathodiyil Nandanan,
Soo-Yeon Jang,
Stefano Moro,
Hea Ok Kim,
Maqbool A. Siddiqui,
Pamela Russ,
Victor E. Marquez,
Roger Busson,
Piet Herdewijn,
T. Kendall Harden,
José L. Boyer, and
Kenneth A. Jacobson
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843-858
5,6-Dihydropyran-2-ones Possessing Various Sulfonyl Functionalities: Potent Nonpeptidic Inhibitors of HIV Protease
Frederick E. Boyer,
J. V. N. Vara Prasad,
John M. Domagala,
Edmund L. Ellsworth,
Christopher Gajda,
Susan E. Hagen,
Larry J. Markoski,
Bradley D. Tait,
Elizabeth A. Lunney,
Alexander Palovsky,
Donna Ferguson,
Neil Graham,
Tod Holler,
Donald Hupe,
Carolyn Nouhan,
Peter J. Tummino,
A. Urumov,
Eric Zeikus,
Greg Zeikus,
Stephen J. Gracheck,
James M. Sanders,
Steven VanderRoest,
Joanne Brodfuehrer,
Krishna Iyer,
Michael Sinz,
Sergei V. Gulnik, and
John W. Erickson
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859-872
1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa
David K. Herron,
Theodore Goodson, Jr.,
Michael R. Wiley,
Leonard C. Weir,
Jeffrey A. Kyle,
Ying K. Yee,
Ann Louise Tebbe,
Jennifer M. Tinsley,
David Mendel,
John J. Masters,
Jeffry B. Franciskovich,
J. Scott Sawyer,
Douglas W. Beight,
Andrew M. Ratz,
Guy Milot,
Steven E. Hall,
Valentine J. Klimkowski,
James H. Wikel,
Brian J. Eastwood,
Richard D. Towner,
Donetta S. Gifford-Moore,
Trelia J. Craft, and
Gerald F. Smith
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873-882
N2-Aroylanthranilamide Inhibitors of Human Factor Xa
Ying K. Yee,
Anne Louise Tebbe,
Jared H. Linebarger,
Douglas W. Beight,
Trelia J. Craft,
Donetta Gifford-Moore,
Theodore Goodson, Jr.,
David K. Herron,
Valentine J. Klimkowski,
Jeffrey A. Kyle,
J. Scott Sawyer,
Gerald F. Smith,
Jennifer M. Tinsley,
Richard D. Towner,
Leonard Weir, and
Michael R. Wiley
[Full Article -
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883-899
Structure-Based Design of Potent, Amidine-Derived Inhibitors of Factor Xa: Evaluation of Selectivity, Anticoagulant Activity, and Antithrombotic Activity
Michael R. Wiley,
Leonard C. Weir,
Steven Briggs,
Nancy A. Bryan,
John Buben,
Charles Campbell,
Nickolay Y. Chirgadze,
Richard C. Conrad,
Trelia J. Craft,
James V. Ficorilli,
Jeffry B. Franciskovich,
Larry L. Froelich,
Donetta S. Gifford-Moore,
Theodore Goodson, Jr.,
David K. Herron,
Valentine J. Klimkowski,
Kenneth D. Kurz,
Jeffery A. Kyle,
John J. Masters,
Andrew M. Ratz,
Guy Milot,
Robert T. Shuman,
Tommy Smith,
Gerald F. Smith,
Ann Louise Tebbe,
Jennifer M. Tinsley,
Richard D. Towner,
Alexander Wilson, and
Ying K. Yee
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900-910
Selective ETA Antagonists. 5. Discovery and Structure-Activity Relationships of Phenoxyphenylacetic Acid Derivatives
Peter C. Astles,
Thomas J. Brown,
Frank Halley,
Caroline M. Handscombe,
Neil V. Harris,
Tahir N. Majid,
Clive McCarthy,
Iain M. McLay,
Andrew Morley,
Barry Porter,
Alan G. Roach,
Carol Sargent,
Christopher Smith, and
Roger J. A. Walsh
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911-920
Inhibition of Grb2 SH2 Domain Binding by Non-Phosphate-Containing Ligands. 2. 4-(2-Malonyl)phenylalanine as a Potent Phosphotyrosyl Mimetic
Yang Gao,
Juliet Luo,
Zhu-Jun Yao,
Ribo Guo,
Hong Zou,
James Kelley,
Johannes H. Voigt,
Dajun Yang, and
Terrence R. Burke, Jr.
[Full Article -
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921-944
Conformationally Constrained Analogues of Diacylglycerol (DAG). 16. How Much Structural Complexity Is Necessary for Recognition and High Binding Affinity to Protein Kinase C?
Kassoum Nacro,
Bruno Bienfait,
Jeewoo Lee,
Kee-Chung Han,
Ji-Hye Kang,
Samira Benzaria,
Nancy E. Lewin,
Dipak K. Bhattacharyya,
Peter M. Blumberg, and
Victor E. Marquez
[Full Article -
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945-952
Design and Synthesis of 13,14-Dihydro Prostaglandin F1 Analogues as Potent and Selective Ligands for the Human FP Receptor
Yili Wang,
John A. Wos,
Michelle J. Dirr,
David L. Soper,
Mitchell A. deLong,
Glen E. Mieling,
Biswanath De,
Jack S. Amburgey,
Eric G. Suchanek, and
Cynthia J. Taylor
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953-970
Substituent Effects on the Antibacterial Activity of Nitrogen-Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis
Michael J. Genin,
Debra A. Allwine,
David J. Anderson,
Michael R. Barbachyn,
D. Edward Emmert,
Stuart A. Garmon,
David R. Graber,
Kevin C. Grega,
Jackson B. Hester,
Douglas K. Hutchinson,
Joel Morris,
Robert J. Reischer,
Charles W. Ford,
Gary E. Zurenko,
Judith C. Hamel,
Ronda D. Schaadt,
Douglas Stapert, and
Betty H. Yagi
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971-983
Design, Synthesis, and Enzymatic Evaluation of Multisubstrate Analogue Inhibitors of Escherichia coli Thymidine Phosphorylase
Antonio Esteban-Gamboa,
Jan Balzarini,
Robert Esnouf,
Erik De Clercq,
María-José Camarasa, and
María-Jesús Pérez-Pérez
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984-994
Synthesis of N-Substituted 4-(4-Hydroxyphenyl)piperidines, 4-(4-Hydroxybenzyl)piperidines, and (±)-3-(4-Hydroxyphenyl)pyrrolidines: Selective Antagonists at the 1A/2B NMDA Receptor Subtype
Anthony P. Guzikowski,
Amir P. Tamiz,
Manuel Acosta-Burruel,
Soo Hong-Bae,
Sui Xiong Cai,
Jon E. Hawkinson,
John F. W. Keana,
Suzanne R. Kesten,
Christina T. Shipp,
Minhtam Tran,
Edward R. Whittemore,
Richard M. Woodward,
Jon L. Wright, and
Zhang-Lin Zhou
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995-1010
New Azolidinediones as Inhibitors of Protein Tyrosine Phosphatase 1B with Antihyperglycemic Properties
Michael S. Malamas,
Janet Sredy,
Iwan Gunawan,
Brenda Mihan,
Diane R. Sawicki,
Laura Seestaller,
Donald Sullivan, and
Brenda R. Flam
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1011-1018
2-Substituted Tryptamines: Agents with Selectivity for 5-HT6 Serotonin Receptors
Richard A. Glennon,
Mase Lee,
Jagadeesh B. Rangisetty,
Malgorzata Dukat,
Bryan L. Roth,
Jason E. Savage,
Ace McBride,
Laura Rauser,
Sandy Hufeisen, and
David K. H. Lee
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1019-1028
Monocyclic L-Nucleosides with Type 1 Cytokine-Inducing Activity
Kanda S. Ramasamy,
Robert C. Tam,
Josie Bard, and
Devron R. Averett
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BRIEF ARTICLES
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1029-1033
N-Terminal Dipeptides of D(-)-Penicillamine as Sequestration Agents for Acetaldehyde
Jonathan F. Cohen,
James A. Elberling,
Eugene G. DeMaster,
Renee C. Lin, and
Herbert T. Nagasawa
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1034-1040
Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant: Lead Identification and SAR of 3- and 4-Substituted Derivatives
Michael J. Genin,
Carolyn Biles,
Barb J. Keiser,
Susan M. Poppe,
Steven M. Swaney,
W. Gary Tarpley,
Yoshihiko Yagi, and
Donna L. Romero
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